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In search of an Aids vaccine. After a disappointing year of research findings, scientists are little closer to developing the Holy Grail of Aids prevention - a successful vaccine. But researchers, doctors and activists still hope to find success by the end of the decade
Carefully optimistic
At stake is a way to stop the transmission of Aids without relying on humans to reduce their tendencies toward risky sexual behaviour. If scientists are successful, the disease could head toward decline.
All of us are cautiously optimistic, says Wayne Koff, senior vice president of research and development at the International Aids Vaccine Initiative, an advocacy organisation.
The epidemic, which began more than two decades ago, has killed an estimated 23 million to 25 million people worldwide so far.
Surprising findings
Researchers earlier this year reached the end of the most extensive vaccine study to date - the so-called AIDSVAX vaccine that was administered to people in the United States.
To the astonishment of experts, the vaccine failed to protect against Aids infection among whites and Latinos, but worked quite well for blacks and Asians. Many critics quickly discounted the study, saying it was too small because only a few hundred non-whites were included among the 5 400 subjects. Others wondered if some genetic difference between the races could account for the discrepancy.
In November, researchers released the results of another study that examined a variation on the AIDSVAX vaccine geared toward Aids strains that are common in Asia. The vaccine, given to half of a group of 2 546 intravenous drug users in Thailand, failed to do any better than a placebo given to the other half.
Vaccines, of course, are available to combat a variety of diseases, from mumps and measles to smallpox and polio. Even chicken pox, the usually mild but sometimes disfiguring perennial disease of childhood, has given up the ghost to a vaccine.
Why the challenge?
Considering the record of vaccine success, why is Aids such a challenge?
There are two hurdles, says Dr Steve Black, director of the Kaiser Permanente Vaccine Study Center in California. One is that the virus itself is attacking the immune system. It's attacking your body's main defense against the disease. Even if you have a vaccine that generates an appropriate immune response, there's no way to make sure the infection itself won't undermine that.
The other challenge lies in the ability of HIV - the Aids virus - to morph into different forms. Other diseases simply don't do that, Black says. Measles is measles, pretty much. If you vaccinate people, they're protected.
Aids, on the other hand, is more like the influenza virus, which changes so often that pharmaceutical companies must tinker with the formulation of flu vaccines each year. HIV does that at even a faster clip, Black says.
A live attenuated vaccine
One possible solution for the first part of the challenge would be to use what's called a live attenuated vaccine - a harmless, weakened form of the Aids virus that would force the immune system to permanently create antibodies, the microscopic soldiers permanently on guard against a specific germ.
The polio vaccine, among others, works in that way. When the body sees the polio virus, it can attack and neutralise it, you don't get the disease, Koff says.
But there's a problem. In HIV, you can elicit a lot of antibodies and they can bind to HIV, but most of them are not effective in neutralising HIV in the right way, Koff says.
Combination vaccine
Koff and other experts suspect that the most feasible approach may be to design a combination vaccine that both primes the immune system and arms cells themselves against the bits of virus that make it past the first wall of defense. The second part of the vaccine would stimulate the immune system to produce cells that are capable of killing the virally infected cells, Koff says. It's not the first line of defense. It's the next line of defense.
For now, a useable vaccine appears to be years off. While about 20 vaccines are in or near the stage of studies in humans, only the AIDSVAX vaccines and one more vaccine have reached the final phases of research, Koff says. Results of the study of the latter vaccine, derived from a canary virus, are pending.
It's conceivable to have a partially effective vaccine by the end of the decade, Koff says. It can have significant benefit on the public health. Remember that 15 000 people a day are becoming infected with HIV. Even if you have a vaccine that's 40 to 50 percent effective, you can make a significant amount of impact. - ( health24.com )
Research by health campaigners found the salt in a portion of his Spicy Olive, Garlic and Tomato Pasta Sauce is equivalent to more than ten bags of ready-salted crisps.
The sauce contained 3g of salt per 100g, making it more salty than sea water.
Consuming half a jar would equate to 5.3g of salt, which is 88 per cent of the maximum amount an adult is recommended to eat in a day.
Loyd Grossman has also been named and shamed in a study published by Consensus Action on Salt and Health (CASH).
His bolognese sauce contains 1.5g of salt per 100g, five times more than the level found in Asda's Good For You Bolognese.

CASH found that brands associated with TV celebrities generally had more salt than supermarket own-label sauces.
The level in Oliver's pasta sauce was some 30 times the figure in WeightWatchers' Roasted Garlic Pasta Sauce.
Oliver's Green Pesto Sauce also contains 3g of salt per 100g, although it is eaten in smaller quantities.
Food firms insist salt is used for good reasons, both because it delivers the taste that customers want and, often, as a preservative.
However, CASH said manufacturers should be able to bring the salt level down to match those it considers to be best.
CASH chairman, Graham MacGregor, a professor of cardiovascular medicine, said: 'Atlantic seawater has 2.5g of salt per 100g. A couple of Jamie Oliver's sauces are even higher than that.
'I think one problem is that a lot of the famous chefs unknowingly are salt addicts. They get used to eating lots of it and their salt taste receptors get suppressed.
'It would be really interesting to measure Jamie's daily intake of salt.'
The Oliver pasta product says half a jar equals one serving.
However, a spokesman for the chef said this would be enough for two or three people.
He added: 'Jamie spent a lot of time working on these sauces and they are designed to be eaten in the Italian way - one jar with at least 500g of pasta - feeding four to six people.
'Because they are more concentrated than rivals you don't need as much and the salt content is dissipated.'
• The BBC is to broadcast a five-part series celebrating the 40-year career of Delia Smith. Starting in January, Delia Through The Decades will assess the impact she has had on our eating habits.
( dailymail.co.uk )
The treatment, which appears to have no side affects, killed all traces of the 'small cell' version of the cancer in more than 50 per cent of the British trials on laboratory mice. It also blocked the cells' ability to resist standard chemotherapy treatment.
A fifth of lung cancer patients have the 'small cell' form, in which the tumours spread so quickly they can rarely be removed. Only 3 per cent of sufferers can expect to survive five years after diagnosis.
Professor Michael Seckl, head of Molecular Oncology and Lung Cancer Research at Imperial College, which led the research, said he hoped to start clinical trials with human patients as early as next year.

'Around one in five of those people will have small cell lung cancer. Although it responds to chemotherapy initially, the tumours soon become resistant to treatment and sadly nearly all people with the disease do not survive.'
The drug, currently known by the codename PD173074, wiped out 50 per cent of 'small cell' lung cancer tumours in one strain of laboratory mice. In other animals it slowed the growth of tumours and prevented them becoming resistant to chemotherapy treatment.
Professor Seckl said: 'We urgently need to develop new treatments for this disease.
'Our new research in mice suggests that it may be possible to develop the drug PD173074 into a new targeted therapy for small cell lung cancer.
'An added bonus of this drug is that it could be taken orally, which would make it less invasive than some other forms of cancer therapy.'
Each year around 39,000 people are diagnosed with lung cancer in the UK and 34,500 die from the disease.
It is the most common cause of lost lives due to cancer in the UK, accounting for nearly a quarter of deaths in men and a fifth in women, and the second most common cancer in men after prostate cancer.
Smoking is responsible for 90 per cent of the cases of lung cancer in men and more than 80 per cent of the cases in women.
Standard treatment for 'small cell' lung cancer is chemotherapy, sometimes accompanied by radiotherapy, which has harsh side effects.
Although the treatment often starts to work, the cancer usually grows back rapidly and becomes resistant.
The new research focused on blocking the activity of a growth hormone called FGF-2 which spurs on the proliferation of small cell lung tumours.
As well as adding fuel to the cancer fire, the hormone also triggers a survival mechanism in tumour cells that makes them immune to chemotherapy drugs.
The research was partly funded by the Department of Health, together with the charities Cancer Research UK and the Cancer Treatment and Research Trust.
Dr Joanna Owens, from Cancer Research UK, said: 'The early results from this study are impressive but we'll need to wait for the results of clinical trials before we'll know if the drugs could work for patients.' ( dailymail.co.uk )
It has overtaken France - which has a larger population - to become the abortion capital of the continent.
The rising rate has been pushed up by abortions among teenage girls, which increased by nearly a third over the past decade.
Half of all pregnancies among girls under 18 in Britain end in abortion.
Anti-abortion campaigners said the figures were an indictment of the Government's teenage pregnancy strategy.

An increase in terminations among teenagers has seen Britain's abortion rate rise (Posed by model)
The figures, collated by a European pressure group, showed that the 219,336 abortions carried out in England, Wales and Scotland in 2007 topped the 209,699 in France to put Britain at the top of the abortion count for the first time.
Both countries remain far ahead of the other nations where abortion is frequent, including Romania, at just over 150,000, Italy, with 127,000, and Spain, 112,000.
Abortion numbers are rising fastest in Spain, but from a much lower base than in Britain.
By contrast, abortion numbers in France have remained virtually steady for the last ten years.
The figures were collated by the Institute for Family Policies from those collected by the European Union's statistical arm Eurostat.
The Norway-based pro-family pressure group presented them to the European Parliament yesterday as part of a report on developments in family life.
It said the annual number of abortions in the EU equals the combined population of its ten smallest member states.
More than half occurred in Britain, France and Romania.
Britain was the country where most teenage girls have abortions - 48,150 abortions among girls under 20 in 2007 against 31,779 in France.

The group said of the overall figures: 'Declines in Germany and Italy, and stagnation in France, are remarkable.'
Britain now ranks fifth in the world for the number of abortions, behind Russia, the U.S., India and Japan.
Abortion campaigners blamed Labour's policies, and in particular its Teenage Pregnancy Strategy, based on promoting sex education and contraception.
Phyllis Bowman of Right to Life said: 'These are not surprising figures.
The Government is not so much running a Teenage Pregnancy Strategy as a Teenage Abortion Strategy.
Conceptions are not going down and abortion is going up, exactly the reverse of what was supposed to happen.
'Britain will continue to have record abortion levels until ministers recognise the idiocy of these policies.'
The Teenage Pregnancy Strategy has cost more than £300million.
But in 2007 pregnancies among girls under 18 in England and Wales went up, not down, and targets for halving 1998 conception levels by next year appear far beyond reach.
Teenagers who become pregnant are increasingly turning to abortion.
Many of them are thought to be girls who aspire to education and a career rather than a life of single motherhood on benefits.
Ministers said yesterday they believe abortions and conceptions among teenagers are set to fall.
Children's Minister Dawn Primarolo said: 'The trends in the data for 2008 and under-18 conception data for the first two quarters of 2008 give me confidence that we will see a return to the downward trend established between 1998 and 2006.'
Last year, £42million was spent - of which £17million was wasted because managers are paying too much for chlamydia tests, said the National Audit Office.
Of those who are tested, one in eight may never receive treatment - putting others at needless risk of developing the condition.
Six years after the programme was launched the rates of chlamydia, which can cause infertility in girls, are still rising.
Only around half of health trusts are testing enough young people to have a significant impact on the rate.
The report says the failure to make progress is largely down to a lack of support from GPs - because chlamydia screening is not part of their performance-related pay scheme. ( dailymail.co.uk )
Just one in five of the 180,000 dementia patients prescribed the anti-psychotic drugs benefit, meaning nearly 150,000 are given them needlessly.
But one in 100 is condemned to an early death, while many more suffer debilitating side-effects, leading critics to claim the risks outweigh the benefits.
Experts believe the problem has grown worse since NHS funding was restricted to patients with 'moderate' cases of dementia in 2006.
Deaths: The 'chemical cosh' drugs may have been given to nearly 150,000 dementia patients needlessly
The drugs are used to sedate patients if they grow agitated, to make life easier for their carers.
These 'chemical cosh' drugs are not licensed to treat dementia but are prescribed to control associated problems such as delusions, sleep disturbance and aggressive behaviour.
But the Government-commissioned report confirms fears that their long-term use aggravates other medical conditions, accelerates mental decline and causes premature death.
Care services minister Phil Hope yesterday backed an action plan to cut the 'unacceptable' use of anti-psychotics by two-thirds over the next three years.
The report's author, Sube Banerjee, professor of mental health and ageing at the Institute of Psychiatry, King's College London, said up to a quarter of people with dementia are on the drugs at any time, with only 36,000 deriving any benefits.
He said they should be used as a 'last resort' for three months at the lowest dose, with a review at the end of this period. He said it was a 'major NHS issue' that many people got 'relatively small' benefits compared with the potential dangers.
Professor Banerjee said that 20 or 30 years ago, 30 per cent of those living in care homes had dementia, whereas 80 or 90 per cent of residents were now affected.
Pointing to the growing burden of elderly patients with Alzheimer's and similar diseases, he said: 'What we have here is an overall failure of health and social care systems to adjust to a changing world.'
Professor Banerjee recommended more psychological therapies and an audit of how many prescriptions are written, as well as improved training for staff looking after dementia patients to stop them simply relying on drugs.
Mr Hope said these ideas would all be implemented, as well as the creation of a national clinical director of dementia.
Neil Hunt, chief executive of the Alzheimer's Society, said: 'This goes beyond quality of care - we see it as a fundamental human rights issue. Almost 150,000 people are being inappropriately prescribed these drugs as a chemical restraint.
'The scandalous over-prescription of anti-psychotic drugs leads to an estimated 1,800 deaths a year. It must end.'
Nadra Ahmed, chairman of the National Care Homes Association, said GPs were not spending enough time visiting care homes to review medication.
Liberal Democrat MP Paul Burstow, who has led a ten-year campaign on the issue, said: 'This review comes much too late for thousands of elderly people whose lives have been cut short by the reckless prescribing of anti-psychotic drugs.
'The evidence that anti-psychotic drugs do more harm than good has been mounting for years.' ( dailymail.co.uk )
But the health-boosting mineral they contain may also push up cholesterol levels and raise the risk of heart disease, researchers claim.
Warning: Selenium - a trace mineral found in Brazil nuts - could raise cholesterol levels
The findings came in a study suggesting that a high level in the blood of selenium - a trace mineral found naturally in Brazil nuts, grain, fish and meat - increases cholesterol levels.
Those found in tests to have the highest level of the mineral in their blood were regularly taking dietary supplements containing selenium.
However, eating large quantities of Brazil nuts and selenium-rich foods might have the same effect.
Researchers at Warwick University say they have discovered that high selenium levels are 'associated' with a 10 per cent rise in cholesterol.
The warning emerges from data on 1,042 people aged 19 to 64 who took part in the UK National Diet and Nutrition Survey between 2000 and 2001.
In those with blood selenium concentrations higher than 1.20micromoles per litre, the levels of total cholesterol were raised by an average of 8 per cent. Levels of a 'bad' type of cholesterol associated with heart disease were increased by 10 per cent.
The study did not take account of the health of individuals or whether they were taking cholesterol-lowering drugs.
High cholesterol levels are a risk factor for heart disease and stroke. Brazil nuts are exceptionally rich in selenium, although average intake of the mineral in the UK is only around half the recommended level.
Dr Saverio Stranges, who led the study reported in the Journal of Nutrition, said: 'We believe that the widespread use of selenium supplements, or of any other strategy that artificially increases selenium status above the level required, is unwarranted at the present time.'
Dr Carrie Ruxton, independent nutrition adviser to the industry-backed Health Supplements Information Service, said the study authors admitted they couldn't be sure whether the association they found 'was due to increased dietary selenium or other factors'.
She added: 'It is premature to suggest at this stage that taking selenium supplements is harmful for heart health.' ( dailymail.co.uk )
Only recently scientists at the European Food Safety Agency (EFSA) threw out 180 health claims made for probiotics (such as 'maintains digestive comfort' or 'boost defences') on the basis that there simply wasn't enough evidence.
Yet nearly 60 per cent of UK households regularly buy probiotic drinks, supplements and yoghurts, so are they wasting money?

Friendly bacteria drinks can ease constipation and irritable bowel symptoms
While there may be erroneous or unvalidated claims for specific products, many experts disagree with the EFSA stance, says Glenn Gibson, Professor of Food Microbiology at Reading University, a leading authority on gut bacteria.
'There's convincing evidence that the right products will do us good,' he says.
Specifically, 'a properly formulated probiotic drink or pills should benefit people who are travelling abroad and coming into contact with different bugs that might upset their system'.
'The right product should minimise the effects of a gut infection,' Professor Gibson adds.
Probiotics can have a preventative effect, too, he says, which is why they are worth taking on a daily basis. They work by crowding out bad bacteria.
There's emerging evidence that some probiotics may stimulate cells of the gut immune system, possibly causing them to secrete molecules which then enter the bloodstream, improving immune response.
But which products are worth trying?
Professor Gibson's view is that, generally, all probiotics are worth taking - at worst they will do you no harm and even poorer quality products will make some difference.
Here, he offers his verdict on various popular products. . .
MORRISONS ACTIVE YOGHURT DRINK

99p for 4 x 100ml
Cost per dose: 25p
Number of bacteria: 1 billion
Type: Bifidobacterium lactis Bb12
Expert verdict: 'This contains a good amount of probiotic bacteria and a useful amount of the prebiotic, inulin.
Prebiotics aren't in themselves bacteria, but boost their number by "feeding" them.
Prebiotics can also improve gut flora (microscopic organisms in the digestive tract) longer term, whereas the action of probiotics is always transient.
'I'm a big fan of products that combine pro and prebiotics, and this is the product I currently buy.'
Rating: 9/10
YEO VALLEY ORGANIC PROBIOTIC YOGHURT DRINK
£1.39 for 500g
Cost per dose (125g): 35p
Number of bacteria: 125 million
Types: Lactobacillus acidophilus and Bifidobacterium bifidum
Expert verdict: 'There's no information on the specific strain of bacteria here, but this product contains reasonable numbers. And even if you don't get significant digestive benefits, it's still a calcium-rich healthy food.
'Lactobacillus acidophilus is well tested and widely used, but not as effective as some Bifidobacteria species. Ideally, formulations with Lactobacillus acidophilus should contain Bifidobacteria, too.'
Rating: 3/10
ACTIMEL

£2.59 for 8
Cost per dose: 32p
Number of bacteria: 10 billion
Type: Lactobacillus casei immunitass DN-114 001
Expert verdict: 'Contains large amounts of a unique strain of a well-researched probiotic. It may help with antibiotic-associated diarrhoea, or that caused by C. difficile.
'It could also help minimise or stop traveller's diarrhoea or a stomach bug.
'A study indicated Actimel may reduce severity of wintertime infections in the elderly, and could help the body respond better to flu vaccinations.'
Rating: 9/10
TESCO NATURAL DEFENCES
£1.49 for 6 x 100g
Cost per dose: 25p
Number of bacteria: 100 million
Type: Lactobacillus casei
Expert verdict: 'A supermarket copy of Actimel, with probably similarly beneficial effects.
'But the strain of bacteria won't be the same, and it has fewer bacteria, too - which could make a difference to its efficacy. It's likely to be better for health maintenance rather than specific ills.'
Rating: 5/10
QUEST L. PLANTARIUM 299V
£10.99 for 30 capsules, from health food stores
Cost per dose: 37p
Number of bacteria: 1 billion
Type: Lactobacillus plantarum 299v
Expert verdict: 'The strain used here has been shown to combat the unpleasant gut symptoms linked to clostridia bacteria (which includes C. difficile).
'In theory, it would be good to take before a stay in hospital, but there are different strains of lactobacillus plantarum bacteria, and I can't guarantee the efficacy of this one.'
Rating: 6/10
YAKULT

£2.50 for 7 x 65ml
Cost per dose: 36p
Number of bacteria: 6.5 billion
Type: Lactobacillus casei Shirota
Expert verdict: 'A well tested product, good for digestive health. There's evidence this strain makes parts of the immune system react less strongly - perhaps dampening down allergic reactions.'
Rating: 9/10
TESCO BASICS PROBIOTIC DRINK
50p for 4 x 100g
Cost per dose: 12.5p
Number of bacteria: 100 million
Type: Lactobacillus acidophilus LA-5
Expert verdict: 'This may help bolster your system against digestive upset, at a bargain price, but the number of bacteria are a bit low compared with products used successfully in clinical trials.
'Lactobacillus acidophilus is not as effective as some Bifidobacteria species, so ideally should contain some of these, too.'
Rating: 5/10
ACTIVIA YOGHURT STRAWBERRY

£1.55 for 4 x 125g
Cost per dose: 39p
Number of bacteria: 4.25 billion
Type: Bifidobacterium animalis DN-173 010
Expert view: 'This strain has been proven to reduce the time food takes to travel through the colon by 21per cent, so it can help with constipation. It also helps reduce the bloating that accompanies irritable bowel syndrome.
'But, you have to consume more probiotic yoghurt than drink to get adequate bacteria, so you may get more sugar (swap to the natural yoghurt version if this is an issue).'
Rating: 8/10
BIOCARE BIOACIDOPHILUS FORTE 7
£5.82 for 7 capsules
Cost per dose: 83p
Number of bacteria: 24 billion
Type: Lactobacillus acidophilus CLT-60 and CUL-21 and Bifidobacterium bifidum CUL-17 and CUL-20
Expert verdict: 'This has high levels of bacteria - particularly good if you're replacing bacteria wiped out by antibiotics.
'I can't vouch for these particular strains, although the manufacturers claim this formulation has been tested by patients taking antibiotics.'
Rating: 5/10
MULTIBIONTA

£4.59 for 30 tablets
Cost per dose: 15p
Number of bacteria: 10 million
Type: Lactobacillus gasseri PA 16/8, Bifidobacterium bifidum MF 20/5, Bifidobacterium longum SP 07/3
Expert verdict: 'The number of bacteria is the minimum dose I'd consider useful.
'However, the tablets have a coating that resists stomach acid, so more bacteria should survive. In clinical studies people reported suffering fewer colds or reduced cold and flu symptoms.'
Rating: 7/10
MULLER VITALITY YOGHURT
£1.90 for 6 x 100g
Cost per dose: 32p
Number of bacteria: 1billion
Type: Bifidobacterium sp. BB-12
Expert view: 'Contains bifidobacteria - the bacteria that starts to reduce in the gut as we get older, causing us to be more prone to gut infections.